Detecting bacterial taxa for predicting adverse pregnancy outcomes

US10683557B2 · kind B2 · utility

Assignee

• The Chinese University of Hong Kong · CN

Inventors

• Stephen Siu Chung Chim · Kowloon, CN
• Chee Yin Cheung · Hong Kong, CN
• Wan Chee Cheung · Hong Kong, CN
• Meng Meng · Shanghai, CN
• Tak Yeung Leung · Sha Tin, CN
• Keun-Young Lee · Seoul, KR

Key dates

• Filing date: Jun 23, 2015
• Grant date: Jun 16, 2020
• Expiry date: Jun 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/16
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. In addition, it provides a method for determining the risk of having advanced cervical dilation and/or premature cervical shortening based on differentially abundant bacterial taxa.