Associating somatic gene mutations in glycophorin a with complex multifactorial diseases
US10684293B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 2014 |
| Grant date | Jun 16, 2020 |
| Priority date | — |
| Expiry date | Jul 23, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/28
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In the detection of a complex multifactorial disease, an MN blood group typing is performed on a first blood sample of a subject to be tested for a complex multifactorial disease, and on a second blood sample of a control subject having known phenotypes. Erythrocytes from the samples are isovolumetrically sphered, and M alleles and N alleles expressed on surfaces of erythrocyte cells of the first and second blood samples are labeled by contacting the blood samples with anti-M antibodies and anti-N antibodies associated with a marker. Labeled M alleles and labeled N alleles in the first and second blood samples are detected and quantified using the marker, in order to determine an incidence of somatic mutations in Glycophorin A of the patient. The incidence is compared with data pertaining to patients with a known complex multifactorial disease, to diagnose the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.