Physically and chemically stable oral suspensions of givinostat

US10688047B2 · kind B2 · utility

Assignee

• ITALFARMACO SPA · IT

Inventors

• Giuseppe Colombo · Piossasco, IT
• Roberta Artico · Milano, IT
• Paolo Mascagni · Sesto San Giovanni, IT
• Maria Valmen Monzani · Milano, IT
• Silvia Puccianti · Magenta, IT

Key dates

• Filing date: Oct 28, 2016
• Grant date: Jun 23, 2020
• Expiry date: Oct 28, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.