Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
US10688330B2 · kind B2 · utility
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30Claims
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Key dates
| Filing date | Dec 10, 2015 |
| Grant date | Jun 23, 2020 |
| Priority date | — |
| Expiry date | Jul 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/08001
- WIPO fieldMachine tools
- WIPO sectorMechanical engineering
Abstract
A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.