Method of magnetically aligning and crystallizing membrane proteins
US10688442B2 · kind B2 · utility
2Cited by
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12Claims
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Key dates
| Filing date | Jul 5, 2016 |
| Grant date | Jun 23, 2020 |
| Priority date | — |
| Expiry date | Jan 24, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2323/35
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The disclosure describes a method of forming highly ordered membrane protein crystals. The forming process is done in the presence of a magnetic field to exploit the diamagnetic anisotropy of the membrane protein. Further described is a method of magnetic alignment and crystallization of membrane proteins in two-dimensional (2D) sheets for protein structural characterization and applications in functional devices. Block co-copolymers are used in alternative embodiments to assist with the crystallization process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.