Hydrogen sulfide precursors and conjugates thereof
US10689335B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Apr 4, 2016 |
| Grant date | Jun 23, 2020 |
| Priority date | — |
| Expiry date | Apr 4, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.