Aminoazole derivative

US10689354B2 · kind B2 · utility

Assignee

• Teijin Pharma Limited · JP

Inventors

• Shinnosuke HOSODA · Tokyo, JP
• Gen Unoki · Hino, JP
• Hidekazu Watanabe · Tokyo, JP
• Kosuke Sasaki · Tokyo, JP
• Jun Shibata · Tsukuba, JP
• Emi Yokoyama · Tokyo, JP
• Kyohei Horie · Tokyo, JP
• Kenichiro Takagi · Hino, JP

Key dates

• Filing date: Dec 9, 2016
• Grant date: Jun 23, 2020
• Expiry date: Dec 9, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (Ra)n-A-(CR13R14)0-1—(CR11R12)0-1; A represents aryl, heteroaryl; R1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R31R32NCO—; R4 and R5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.