Triazole pyridyl compounds as agonists of the APJ receptor

US10689367B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Yinhong Chen · Hayward, US
• Alan C. Cheng · Cambridge, US
• Mikkel V. Debenedetto · Shrewsbury, US
• Paul John Dransfield · Arlington, US
• James S. Harvey · Arlington, US
• Jonathan Houze · Cambridge, US
• Aarif Yusuf Khakoo · Woodside, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Vatee Pattaropong · Bedford, US
• Gayathri Swaminath · Brisbane, US
• Charles Kreiman · Watertown, US
• David Moebius · Westwood, US
• Ankit Sharma · Quincy, US

Key dates

• Filing date: Nov 3, 2017
• Grant date: Jun 23, 2020
• Expiry date: Nov 3, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.