Patent · US Active

Compositions and methods for treating cancer with DuoCARs

US10689431B2 · kind B2 · utility

6Cited by

0References

9Claims

0Family size

Assignee

LENTIGEN TECHNOLOGY, INC. · US

Inventors

Rimas J. Orentas · Seattle, US
Dina Schneider · Potomac, US
Waleed M. Haso · Santa Monica, US
Stefan Miltenyi · Wittlich, DE
Boro Dropulic · Ellicott City, US

Key dates

Filing date	Sep 18, 2018
Grant date	Jun 23, 2020
Priority date	—
Expiry date	Sep 18, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.