Method of inhibiting macrophage activation using an inhibitor of PARP9
US10689651B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 14, 2014 |
| Grant date | Jun 23, 2020 |
| Priority date | — |
| Expiry date | Jul 18, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y204/0203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies. Modulating the expression and/or activity of PARP9 and/or PARP14 allows the inhibition of monocytes or macrophage M1 activation and inflammation. Inhibiting undesirable excessive or sustained inflammation found in humans, for the treatment, prevention and/or management of conditions where undesirable excessive or sustained inflammation is known or likely to contribute to the onset, development and/or progression the conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.