Methods of screening and treatment with USP4 inhibitors
US10690656B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 29, 2016 |
| Grant date | Jun 23, 2020 |
| Priority date | — |
| Expiry date | Jul 19, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to materials and methods for exploiting synthetic lethality and/or chemo-sensitisation in DNA damage response (DDR) pathways. In particular, the application relates to ubiquitin hydrolase protein Ubiquitin Specific Protease 4 (USP4) and its association with DDR pathways. Further, the use of USP4 inhibitors in the treatment of cancer and methods of screening is described, in particular, use of inhibitors of USP4 in the treatment of tumours defective in double-strand break repair (DSBR) and/or tumours resistant to platinum-based chemotherapy, or to sensitise, i.e. chemosensitise or radiosensitise tumours to other therapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.