Spray-dried pharmaceutical compositions comprising active agent nanoparticles
US10695295B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 3, 2014 |
| Grant date | Jun 30, 2020 |
| Priority date | — |
| Expiry date | Mar 3, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 μm, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 μm; at least 50% of the spray-dried particles have a particle size of at least about 15 μm; and at least 90% of the spray-dried particles have a particle size of up to about 55 μm. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally administering the compositions, such as intranasally or intravaginally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.