Glucose conjugates of triptolide, analogs and uses thereof

US10695319B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Jun O. Liu · Clarksville, US
• Qingli He · Baltimore, US
• Martin G. Pomper · Baltimore, US
• Il Minn · Ellicott City, US
• Biao Yu · Shanghai, CN
• Qiaoling Wang · Baltimore, US

Key dates

• Filing date: Feb 3, 2017
• Grant date: Jun 30, 2020
• Expiry date: Feb 3, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.