Inhibitors of bacterial growth

US10695322B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• Rutgers, the State University of New Jersey · US

Inventors

• Gyanu Lamichhane · Towson, US
• Craig A. Townsend · Baltimore, US
• Evan Lloyd · Baltimore, US
• Amit Kaushik · Baltimore, US
• Pankaj Kumar · Madison, US
• Joel Freundlich · Princeton, US
• Shaogang Li · Newark, US
• Sean Ekins · Abington, US
• Nicole Parrish · Peterstown, US

Key dates

• Filing date: Jan 26, 2017
• Grant date: Jun 30, 2020
• Expiry date: Jan 26, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D499/897
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.