Composition and method for detecting hypoxia
US10695446B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 2, 2016 |
| Grant date | Jun 30, 2020 |
| Priority date | — |
| Expiry date | May 2, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7038
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.