Cannabinoid receptor CB2 ligand 4-(aminomethyl)-N,N-dialkylanilines

US10696624B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Xiang-Qun Xie · Dorpsstraat, US
• Abdulrahman Almehizia · Riyadh, SA
• Peng Yang · Tainan, TW

Key dates

• Filing date: Jun 17, 2016
• Grant date: Jun 30, 2020
• Expiry date: Jun 17, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).