Patent · US Active

Modular system and process for the continuous, microbe-reduced production and/or processing of a product

US10696940B2 · kind B2 · utility

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1Claims

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Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Benjamin MAISER · Leverkusen, DE
Peter SCHWAN · Leverkusen, DE
Martin LOBEDANN · Cologne, DE
Volker Möhrle · Neunburg vorm Wald, DE

Key dates

Filing date	Apr 29, 2016
Grant date	Jun 30, 2020
Priority date	—
Expiry date	Dec 16, 2036

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01D2315/16
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

The invention provides a method for the continuous, microbe-reduced production and/or processing of a biopharmaceutical, biological macromolecular product from a heterogeneous cell culture-fluid mixture, comprising the steps of: (a) providing a particle-free fluid from a heterogeneous cell culture-fluid mixture containing the product, in the form of a product stream, (b) at least one filtration, providing a filtrate, (c) at least two chromatography steps for purifying the product, (d) at least one virus depletion, (e) at least one ultrafiltration and/or at least one diafiltration of the product stream of steps (b), (c) and/or (d), characterized in that the at least two chromatography steps from (c) comprise a purification via at least two chromatography columns and/or membrane adsorbers in each case and that the process is carried out in a closed and modular manner The invention further provides a corresponding modular system for carrying out said method.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.