Ketoreductase polypeptides for the synthesis of chiral compounds
US10696953B2 · kind B2 · utility
1Cited by
100References
6Claims
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Key dates
| Filing date | Feb 5, 2016 |
| Grant date | Jun 30, 2020 |
| Priority date | — |
| Expiry date | Feb 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y101/01184
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.