Fusogenic liposome-coated porous silicon nanoparticles

US10702474B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael J. Sailor · Village of La Jolla, US
• Byungji Kim · Cambridge, US
• Jinyoung Kang · Cambridge, US

Key dates

• Filing date: Jul 8, 2016
• Grant date: Jul 7, 2020
• Expiry date: Jul 8, 2036

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y30/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.