4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

US10703735B2 · kind B2 · utility

Assignees

• Lead Discovery Center GmbH · DE
• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Raffaella Di Lucrezia · Wuppertal, DE
• Tim Bergbrede · Dortmund, DE
• Peter Nussbaumer · Schwanenstadt, AT
• Uwe Koch · Roma, IT
• Bert Klebl · Dortmund, DE
• Axel Choidas · Herdecke, DE
• Anke Unger · Dortmund, DE
• Nils-Göran Larsson · Huddinge, SE
• Maria Falkenberg-Gustafsson · Mölndal, SE
• Claes Gustafsson · Belmont, US

Key dates

• Filing date: Jul 23, 2019
• Grant date: Jul 7, 2020
• Expiry date: Jul 23, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.