Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof

US10703756B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Atli Thorarensen · O'Fallon, US
• Matthew Frank Brown · Stonington, US
• Agustin Casimiro-Garcia · Concord, US
• Ye Che · Groton, US
• Mark E. Flanagan · Gales Ferry, US
• Adam Matthew Gilbert · Congers, US
• Matthew Merrill Hayward · Old Lyme, US
• Jean-Baptiste Telliez · Lexington, US
• Rayomand Jal Unwalla · Eagleville, US
• John I. Trujillo · Ledyard, US
• Sidney Liang · Bethany, US

Key dates

• Filing date: Apr 19, 2016
• Grant date: Jul 7, 2020
• Expiry date: Apr 19, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.