Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations

US10703763B2 · kind B2 · utility

Assignee

• ALFASIGMA S.P.A. · IT

Inventors

• Giuseppe Claudio Viscomi · Monterotondo, IT
• Manuela Campana · Bologna, IT
• Donatella Confortini · Bologna, IT
• Maria Barbanti · Bologna, IT
• Dario Braga · Bologna, IT

Key dates

• Filing date: Mar 4, 2019
• Grant date: Jul 7, 2020
• Expiry date: Mar 4, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.