Processes for the preparation of SGLT-2 inhibitors, intermediates thereof

US10703772B2 · kind B2 · utility

Assignee

• Emmennar Pharma Private Limited · IN

Inventors

• Maha Vishnu Mundla · Chilpur, IN
• Sridhar Malyala · Hyderabad, IN
• Chandra Prakash Narani · Kadthal, IN
• Laxmi Narasimha Varaprasad Chintaginjala · Chilpur, IN
• Suresh Kumar Gunukula · Secunderabad, IN
• Bala Yellaiah Chittiboyina · Hyderabad, IN
• Prabhakar Bellam · Chilpur, IN
• Hemalatha Reddy Samireddy · Secunderabad, IN
• Sowmya Dantham · Hyderabad, IN
• Prasad Vure · Secunderabad, IN
• Pooja Kale · Kadthal, IN

Key dates

• Filing date: May 29, 2018
• Grant date: Jul 7, 2020
• Expiry date: May 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.