Prognosing mortality in patients with chronic kidney disease by detecting macrophage inhibitory cytokine-1 (MIC-1)
US10705096B2 · kind B2 · utility
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Key dates
| Filing date | Sep 15, 2016 |
| Grant date | Jul 7, 2020 |
| Priority date | — |
| Expiry date | Sep 15, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (CKD), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytoking-1 (MID-1) in a test body sample from the diseased subject. A method of preventing or reducing the risk of death in a CKD subject which involves removing or inactivating MIC-1 present in the blood, plasma or serum of the subject, is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.