Therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies
US10709677B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jul 2, 2015 |
| Grant date | Jul 14, 2020 |
| Priority date | — |
| Expiry date | Jul 2, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel uses of a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, in treating a disorder associated with the PPP1R15A pathway and associated with protein misfolding stress and in particular with accumulation of misfolded proteins selected in the group of tauopathies, synucleinopathies, polyglutamine and polyalanine diseases, leukodystrophies, cystic fibrosis, multiple sclerosis, lysosomal storage disorders, amyloidosis diseases, inflammation, metabolic disorders, cardio-vascular disorders, osteoporosis, nervous system trauma, ischemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.