Compositions and methods for inhibiting expression of ADAMTS-5 and ADAM17
US10709729B2 · kind B2 · utility
2Cited by
1References
7Claims
0Family size
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Key dates
| Filing date | Dec 23, 2015 |
| Grant date | Jul 14, 2020 |
| Priority date | — |
| Expiry date | Dec 23, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3341
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.