Patent · US Active

Diagnosis of sepsis and systemic inflammatory response syndrome

US10712350B2 · kind B2 · utility

0Cited by

3References

7Claims

0Family size

Assignee

UNIVERSITÄTSKLINIKUM JENA · DE

Inventors

Michael Kiehntopf · Jena, DE
Diana Schmerler · Jena, DE
Thomas Deufel · Jena, DE
Frank Brunkhorst · Jena, DE

Key dates

Filing date	Dec 9, 2016
Grant date	Jul 14, 2020
Priority date	—
Expiry date	Jun 30, 2038

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/56
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates a method for the diagnosis, prediction or risk stratification for mortality and/or disease outcome of a subject that has or is suspected to have sepsis, comprising determining the presence and/or level of antitrypsin (ATT) or fragments thereof in a sample taken from said subject and/or determining the presence and/or level of transthyretin (TTR) or fragments thereof, wherein the presence and/or level of ATT and/or TTR or fragments thereof is correlated with an increased risk of mortality and, wherein said increased risk of mortality and/or poor disease outcome is given if the level of ATT is below a certain cut-off value and/or the level of fragments thereof is above a certain cut-off value and/or said increased risk of mortality and/or poor disease outcome is given if the level of TTR is below a certain cut-off value and/or the level of fragments thereof is below a certain cut-off value. The invention relates in general to the use of ATT and/or TTR or its fragments for the diagnosis of sepsis, and to nucleotides of SEQ ID NO. 2 to 14.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.