Deep brain source imaging with M/EEG and anatomical MRI

US10716485B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• Massachusetts Institute of Technology · US

Inventors

• Pavitra Krishnaswamy · Cambridge, US
• Patrick L. Purdon · Somerville, US
• Gabriel Obregon-Henao · Boston, US
• Matti Hamalainen · Lempäälä, FI
• Behtash Babadi · Brookline, US

Key dates

• Filing date: Nov 9, 2015
• Grant date: Jul 21, 2020
• Expiry date: Nov 15, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/4064
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.