Residence structures and related methods

US10716752B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Andrew Bellinger · Wellesley, US
• Shiyi Zhang · Shanghai, CN
• Carlo Giovanni Traverso · Newton, US
• Robert S. Langer · Newton, US
• Stacy Mo · Darien, US
• Tyler Grant · Arlington, US
• Mousa Jafari · Waltham, US
• Dean Liang Glettig · Cambridge, US
• Angela DiCiccio · San Francisco, US
• Lowell L. Wood, Jr. · Bellevue, US
• Philip A. Eckhoff · Bellevue, US

Key dates

• Filing date: Nov 22, 2019
• Grant date: Jul 21, 2020
• Expiry date: Nov 22, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain embodiments involve gastric residence structures which can be administered to a subject (e.g., a patient) in a configuration constrained by a retaining element, and configured to mediate a change in shape when unconstrained by the retaining element to assume a configuration in the stomach in which is retained and unable to pass through the gastric pyloric orifice of the subject under gastrointestinal physiological conditions. The residence structures can be loaded with an agent for release in the stomach.