Methods for treating autoimmune disease by inducing autoantigen-specific regulatory CD4+ T cells
US10716836B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 27, 2008 |
| Grant date | Jul 21, 2020 |
| Priority date | — |
| Expiry date | Jan 29, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/515
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods and compositions for the treatment and monitoring the progress of autoimmune diseases. In some embodiments, the methods include the stimulation of regulatory T cells specific to autoantigens associated with the autoimmune disease. A specific embodiment relates to diabetes mellitus, and the prevention or delay of loss of residual β-cell mass, providing a longer remission period and delaying the onset of diabetes related, progressive, complications through immunotherapeutic induction of regulatory T cells specific for human insulin B chain. In addition, the methods described herein can be used to predict whether a subject, e.g., a subject with ongoing anti-insulin autoimmunity, will progress to T1DM, and to evaluate a subject's response to a therapeutic intervention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.