Compositions and methods of enhancing immune responses to enteric pathogens

US10716840B2 · kind B2 · utility

Assignees

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Lisa Bielke · Wooster, US
• Sherryll Layton · Fayetteville, US
• Billy Hargis · Fayetteville, US
• Neil R. Pumford · Bentonville, US
• Olivia B. Faulkner · Shawnee, US
• Luc Berghman · College Station, US
• Daad Abi-Ghanem · Tigard, US

Key dates

• Filing date: Aug 5, 2019
• Grant date: Jul 21, 2020
• Expiry date: Aug 5, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.