Co-crystal forms of a novobiocin analog and proline

US10717755B2 · kind B2 · utility

Assignee

• REATA PHARMACEUTICALS HOLDINGS, LLC · US

Inventors

• Xin Jiang · Coppell, US
• John A. Walling · Round Lake Beach, US
• Melanie Janelle Bevill · West Lafayette, US
• Christopher Scott Seadeek · West Lafayette, US
• Jared P. Smit · Lafayette, US

Key dates

• Filing date: Feb 1, 2019
• Grant date: Jul 21, 2020
• Expiry date: Feb 1, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.