Patent · US Active

Copolymers as excipients for effective solubilization of poorly water-soluble substances from solid mixtures

US10717799B2 · kind B2 · utility

4Cited by

0References

17Claims

0Family size

Assignees

DOW GLOBAL TECHNOLOGIES LLC · US
Rohm and Haas Company · US
Regents of the University of Minnesota · US

Inventors

Swapnil Tale · Minneapolis, US
Theresa M. Reineke · Vadnais Heights, US
Frank S. Bates · Minneapolis, US
Jeffrey M. Ting · Minneapolis, US
Lakmini Widanapathirana · Minneapolis, US
Steven J. Guillaudeu · Midland, US
Li Guo · Tuji, CN

Key dates

Filing date	Feb 24, 2016
Grant date	Jul 21, 2020
Priority date	—
Expiry date	Feb 24, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08F226/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.