Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein

US10717973B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Michael Breuer · Darmstadt, DE
• Bernhard Hauer · Neheim, DE
• Dieter Jendrossek · Bingen, DE
• Gabriele Siedenburg · Stuttgart, DE
• Juergen Pleiss · Asperg, DE
• Demet Sirim · Stuttgart, DE
• Silvia Fadenrecht · Stuttgart, DE

Key dates

• Filing date: Dec 6, 2018
• Grant date: Jul 21, 2020
• Expiry date: Dec 6, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/52
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.