Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-Fc gene, and comprises knocked-out GGTA1 gene, and use thereof
US10717991B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Nov 11, 2016 |
| Grant date | Jul 21, 2020 |
| Priority date | — |
| Expiry date | Jan 28, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y114/99003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for α-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.