Systems and methods for lesion assessment

US10722301B2 · kind B2 · utility

Assignees

• The George Washington University · US
• 460Medical, Inc. · US

Inventors

• Omar Amirana · Palo Alto, US
• Kenneth C. Armstrong · Cary, US
• James H. Bowen · Belmont, US
• Cinnamon Larson · Carrboro, US
• Marco A. Mercader · Arlington, US
• Terrance Ransbury · Chapel Hill, US
• Narine Sarvazyan · Potomac, US

Key dates

• Filing date: Nov 3, 2015
• Grant date: Jul 28, 2020
• Expiry date: Dec 23, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2218/002
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.