Patent · US Active

Stealth nanocapsules for protein delivery

US10722475B2 · kind B2 · utility

0Cited by

2References

17Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Yunfeng Lu · Los Angeles, US
Yang Liu · Columbus, US
Jing Wen · Sudbury, US
Gan Liu · Dongyang City, CN

Key dates

Filing date	Nov 20, 2015
Grant date	Jul 28, 2020
Priority date	—
Expiry date	Nov 20, 2035

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB82Y5/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N′-methylenebisacrylamide (BIS) crosslinker.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.