Polymer-conjugated METAP2 inhibitors, and therapeutic methods of use thereof
US10722532B2 · kind B2 · utility
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39References
11Claims
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Assignee
Inventor
Key dates
| Filing date | Nov 16, 2018 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Nov 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F220/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.