Methods and compositions for treating and preventing HIV

US10722572B2 · kind B2 · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• Université Paris—Est Créteil Val de Marne · FR
• BAYLOR RESEARCH INSTITUTE · US
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR

Inventors

• Yves Levy · Malakoff, FR
• Gerard Zurawski · San Juan Bautista, US
• Sandra Zurawski · Midlothian, US
• Anne-Laure Flamar · New York, US

Key dates

• Filing date: Dec 10, 2019
• Grant date: Jul 28, 2020
• Expiry date: Dec 10, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16171
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).