Patent · US Active

Targeted antimicrobial photodynamic therapy

US10722582B2 · kind B2 · utility

0Cited by

0References

10Claims

0Family size

Assignee

Purdue Research Foundation · US

Inventors

Alexander Wei · Wilnsdorf, DE
Ana Victoria Morales-de-Echegaray · West Lafayette, US

Key dates

Filing date	Mar 29, 2019
Grant date	Jul 28, 2020
Priority date	—
Expiry date	Mar 29, 2039

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/6929
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates generally to a method and a composition matter that provides a rapid and potent antimicrobial photodynamic inactivation (aPDI) of pathogenic bacteria that express high-affinity cell-surface hemin receptors (CSHRs) using Ga(III)-protoporphyrins IX (GaPpIX or Ga-PpIX). The invention provides an effective treatment option for infections of skin or body cavities that are accessible to visible-light irradiation, such as a handheld LED array emitting visible light (405 nm), especially for infections caused by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), pathogenic staphylococci, Streptococcus mutans, S. pneumoniae, S. pyogenes, streptococci, corynebacteria, mycobacteria, and Bacillus anthracis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.