Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors

US10723723B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Prashantha Gunaga · Savanuru, IN
• Rajeev S. Bhide · Princeton Junction, US
• Rajesh Onkardas Bora · Bengaluru, IN
• Manoranjan Panda · Survanagiri, IN
• Navnath Dnyanoba Yadav · Bengaluru, IN
• Eldon Scott Priestley · Yardley, US
• Jeremy Richter · Ewing, US

Key dates

• Filing date: Nov 2, 2017
• Grant date: Jul 28, 2020
• Expiry date: Nov 2, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.