Azithromycin derivatives with epithelial barrier enhancement properties
US10723752B2 · kind B2 · utility
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13Claims
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Assignee
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Key dates
| Filing date | Nov 21, 2016 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Nov 21, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel compounds that are derivatives of Azithromycin and that have been found by the current inventors to have low antimicrobial activity but significant epithelial barrier enhancement properties. The invention further provides use of the compounds as a medicament, in particular in the treatment or prophylaxis of a disease or condition that is caused by a defect in epithelial cells or tissue, or a disease or condition that benefits from enhancement or restoration of epithelial barrier function, for example diseases of the respiratory tract.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.