Immunoglobulin-binding protein and affinity carrier using same
US10723769B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 24, 2016 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Nov 1, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6854
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided is an affinity chromatography carrier that maintains high immunoglobulin-binding capacity and high alkali resistance. An immunoglobulin-binding protein including at least one modified immunoglobulin-binding domain, the modified immunoglobulin-binding domain being a polypeptide consisting of an amino acid sequence of an immunoglobulin-binding domain selected from the group consisting of the B domain, Z domain, C domain, and variants thereof of Staphylococcus aureus protein A, in which at least one amino acid residue is inserted between positions corresponding to the 3-position and position 4 of the amino acid sequence of the B domain, Z domain or C domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.