Method for purifying darbepoetin alfa
US10723775B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 28, 2014 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Nov 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for purifying darbepoetin alfa by selectively separating only a structural isoform having a high content of sialic acid from a mixture of structural isoforms of darbepoetin alfa having various contents of sialic acid. Since the method of the present invention is a novel method for purifying darbepoetin alfa which can be conveniently and simply produced, it is possible to remarkably increase productivity due to process efficiency improvement, as well as to yield high purity darbepoetin alfa when mass-producing darbepoetin alfa according to the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.