Genetic encoding of chemical post-translational modification for phage-displayed libraries
US10724034B2 · kind B2 · utility
1Cited by
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14Claims
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Key dates
| Filing date | Oct 22, 2015 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Oct 22, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present application provides a method of synthesizing a genetically-encoded chemical modification of a peptide library. A vector in a substrate, such as a phage, is modified to include a peptide linker and a modification to form a genetic “barcode”. The barcode is screened against potential targets which may be used in drug discovery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.