Oligonucleotide compositions and methods thereof

US10724035B2 · kind B2 · utility

Assignee

• WAVE LIFE SCIENCES LTD. · SG

Inventors

• Chandra Vargeese · Schwenksville, US
• Meena · Belmont, US
• Nenad Svrzikapa · Cambridge, US
• Susovan Mohapatra · Belmont, US
• Christopher J. Francis · Arlington, US
• Gregory L. Verdine · Boston, US
• Anna Sokolovska · Somerville, US

Key dates

• Filing date: May 3, 2017
• Grant date: Jul 28, 2020
• Expiry date: May 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/50
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.