Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array

US10724143B1 · kind B1 · utility

Assignee

• CustomArray, Inc. · US

Inventors

• Karl-Heinz Maurer · Erkrath, DE
• John Cooper · Kilmarnock, GB

Key dates

• Filing date: Jun 22, 2018
• Grant date: Jul 28, 2020
• Expiry date: Jun 22, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.