Apparatus and method for determination of the fine particle dose of a powder inhalation formulation
US10724928B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 22, 2016 |
| Grant date | Jul 28, 2020 |
| Priority date | — |
| Expiry date | Jun 13, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/0261
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In an apparatus for collecting aerosolised respirable particles of an inhalable medicinal formulation, aerosolised formulation is drawn pneumatically through a dose collection section comprising an inlet orifice (201) and an air-permeable filter (206), the filter being positioned opposed to said orifice, and extending across the pathway (4) for filtering the pneumatic flow so as to retain particulate material therein on the filter, and the orifice (201) being so dimensioned and configured that it has an unimpeded area that is no less than 75% of the area of the filter (201) on which the dose will be collected. In a method using the apparatus, particles (209, 210) collected on the filter may optionally be subjected to a dissolution test. A good correlation is obtainable between in vitro and in vivo doses with improved independence of loading.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.