Method for predicting risk of exposure to interstitial fibrosis and tubular atrophy with clusterin

US10725026B2 · kind B2 · utility

Assignees

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US
• THE WESTMEAD INSTITUTE FOR MEDICAL RESEARCH · AU
• WESTERN SYDNEY LOCAL HEALTH DISTRICT · AU

Inventors

• Barbara Murphy · Pelham Manor, US
• Philip J. O'Connell · Chatswood, AU

Key dates

• Filing date: Nov 13, 2017
• Grant date: Jul 28, 2020
• Expiry date: Nov 13, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/54
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for identifying a kidney transplant recipient at an increased risk of developing interstitial fibrosis or tubular atrophy which comprises obtaining a post-transplant urine sample from the kidney transplant recipient; measuring the level of clusterin in the urine sample; comparing the level of clusterin in the patient sample to the level of clusterin in a control sample from the urine of a non-fibrotic kidney transplant recipient; diagnosing a kidney transplant recipient with a clusterin level that is significantly higher than the clusterin level in the control as being at an increased risk of developing interstitial fibrosis or tubular atrophy.