Compositions of microbiota and methods related thereto

US10729732B2 · kind B2 · utility

Assignees

• Ethicon Endo-Surgery, Inc. · US
• The General Hospital Corporation · US
• President and Fellows of Harvard College · US

Inventors

• Lee M. Kaplan · Wellesley, US
• Alice P. Liou · Boston, US
• Peter J. Turnbaugh · Somerville, US
• Jason L. Harris · Lebanon, US

Key dates

• Filing date: Oct 30, 2019
• Grant date: Aug 4, 2020
• Expiry date: Oct 30, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.